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Factor XII Deficiency, Variant 1 (Feline)

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Test Overview:

Test breeding cats genetically for the variant. Avoid breeding two carriers as it can produce affected offspring homozygous for the mutation. Breeding carriers to clear cats produces carriers or clear kittens but no affected kittens. Because the condition is asymptomatic and not associated with bleeding, breeding decisions can be balanced with overall genetic diversity and health considerations. Partnership with veterinarians and genetic counsellors is advised to manage breeding responsibly.

Category:

Haemolymphatic - Associated with the blood and lymph

Gene:

F12

Variant Detected:

c.1321delC

Severity:

Low. This disease generally causes mild signs of disease, or can be quite easily treated/managed.

Mode of Inheritance:

Autosomal Recessive

Associated Breed(s):

Mixed Breed / Unknown Breed (Feline),
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