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Congenital Hypothyroidism (Feline)

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Test Overview:

Genetic testing of breeding cats is strongly advised to identify carriers and affected cats. Avoid breeding two carriers to prevent affected kittens. Breeding carrier to clear (non-carrier) cats is acceptable; offspring will be carriers or clear but unaffected. Gradual reduction of mutation frequency through selective breeding is recommended while maintaining genetic diversity.

Category:

Endocrine - Associated with hormone-producing organs

Gene:

TPO

Variant Detected:

c.1333G>A (p.Ala445Thr) and c.430G>A (p.Gly144Arg)

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing can determine if a cat is a carrier of Congenital Hypothyroidism.

Research Citation(s):

Giger, U., Raj, K., Murrow, C.V., Traas, A., Erat, A.M., van Hoeven, M., Mazrier, H., Haskins, M.E. : Congenital hypothyroidism with goiter in cats due to a TPO mutation. J Vet Intern Med 29:448; Abstract ESVE-O-4, 2015

Associated Breed(s):

Mixed Breed / Unknown Breed (Feline),
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