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Juvenile Cataracts (Wirehaired Pointing Griffon Type)

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Test Overview:

Juvenile Cataracts (Wirehaired Pointing Griffon Type) affects dogs and is an inherited eye disease, where the eye lens becomes cloudy and leads to vision loss. Cataracts are opacities in the lens of the eye caused by structural changes in lens proteins. A normal lens allows light to pass through to the Retina in the back of the eye. Light cannot pass through the parts of the lens affected by cataracts and vision becomes blurry. Affected dogs most commonly present with small cataracts that are visible during a veterinary eye exam within a few weeks to months after birth. These may become progressively larger as the dog ages and visual deficits may develop; however, it is unknown if other genetic and environmental factors contribute to this. NOTE: not all forms of cataracts are inherited and environmental factors such as UV damage can also play a role in the severity of disease.

Category:

Ophthalmologic - Associated with the eyes and associated structures

Gene:

FYCO1

Variant Detected:

chr20:42952995 (canFam4): G/-

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the FYCO1 gene will reliably determine if a dog is a genetic carrier of Juvenile Cataracts (Wirehaired Pointing Griffon Type).

Research Citation(s):

Rudd Garces G, Christen M, Loechel R, Jagannathan V, Leeb T. FYCO1 Frameshift Deletion in Wirehaired Pointing Griffon Dogs with Juvenile Cataract. Genes (Basel). 2022 Feb 11;13(2):334. [PubMed: 35205377]

Associated Breed(s):

Mixed Breed,
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