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Exercise Induced Metabolic Myopathy

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Test Overview:

Exercise Induced Metabolic Myopathy affects dogs and is a muscle disorder. It is characterised by muscle weakness, pain, exercise intolerance and sometimes dark urine after exercise due to potential muscle breakdown (rhabdomyolysis). This disease results from a defect in the very long chain of acyl-CoA dehydrogenase (VLCAD) enzyme and consequently leads to metabolic issues after exercise.

Category:

Musculoskeletal - Associated with muscles, bones and associated structures

Gene:

ACADVL

Variant Detected:

nonsense mutation: c. 1728C>A.

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the ACADVL gene will reliably determine if a dog is a genetic carrier of Exercise Induced Metabolic Myopathy.

Associated Breed(s):

Mixed Breed,
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