Congenital Dyshormonogenic Hypothyroidism with Goiter (Shih Tzu)

Category:

Endocrine - Associated with hormone-producing organs

Gene:

SLC5A5

Variant Detected:

c.1172-1G>A chr20

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Thyroid imaging via ultrasound, plasma diagnosis for TT4 and FT4 concentrations

Research Citation(s):

https://pubmed.ncbi.nlm.nih.gov/29777899/

Associated Breed(s):

Maltese Shih tzu, Shih tzu,