Canine Leukocyte Adhesion Deficiency Type I (Irish Setter Type)

Category:

Immunologic - Associated with the organs and cells of the immune system

Gene:

Integrin subunit beta 2 (ITGB2) on chromosome 31

Variant Detected:

c.107G>C

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of all breeding Irish setters prior to entering into breeding programs.

Research Citation(s):

Kijas JM, Bauer Jr. TR, Gafvert S, Marklund S, Trowald-Wigh G, Johannisson A, Hedhammar A, Binns M, Juneja RK, Hickstein DD, Andersson L. A Missense mutation in the beta-2 integrin gene (ITGB2) causes canine leukocyte adhesion deficiency. Genomics. 1999 Oct 1;61(1):101-7. [PubMed: 10512685] Kijas JM, Juneja RK, Gafvert S, Andersson L. Detection of the causal mutation for canine leukocyte adhesion deficiency (CLAD) using pyrosequencing. Anim Genet. 2000 Oct;31(5):326-8. [PubMed: 11105214] Renshaw HW, Davis WC. Canine granulocytopathy syndrome: an inherited disorder of leukocyte function. Am J Pathol. 1979 Jun;95(3):731-44. [PubMed: 453331] Verfaillie T, Verdonck F, Cox E. Simple PCR-based test for the detection of canine leucocyte adhesion deficiency. Vet Rec. 2004 June 26;154(26):821-3. [PubMed: 15260444]

Associated Breed(s):

Irish Red and White Setter, Irish Setter, Mixed Breed,