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White Gloves (Birman Pattern)

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Test Overview:

The KIT gene affects feline coat colour through modifying the expression of the pigments eumelanin and phaeomelanin in the hair, which results in the absence of pigmentation. The wg variant is a mutation in the KIT gene which results in the white feet or 'gloves' in the Birman cat breed. This occurs when two copies of the mutation are present. The clear white gloves are a part of the standard Birman cat breed, and the mutation is therefore essentially fixed in the Birman cat population, and all Birman cats must have two copies of the wg allele.

Category:

Haemolymphatic - Associated with the blood and lymph

Gene:

KIT

Variant Detected:

c.1035_1036delinsCA

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Lyons LA. Feline genetics: clinical applications and genetic testing. Top Companion Anim Med. 2010 Nov;25(4):203-12. PubMed PMID: 21147473 PubMed: 21147473 Montague MJ, Li G, Gandolfi B, Khan R, Aken BL, Searle SMJ, Minx P, Hillier LW, Koboldt DC, Davis BW, Driscoll CA, Barr CS, Blackistone K, Quilez J, Lorente-Galdos B, Marques-Bonet T, Alkan C, Thomas GWC, Hahn MW, Menotti-Reymon M, O’Brien SJ, Wilson RK, Lyons LA, Murphy WJ, Warren WC. Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication. Proc Natl Acad Sci USA. 2014 Dec;111(48):17230-5. PubMed PMID: 25385592 PubMed: 25385592

Associated Breed(s):

Birman, Egyptian Black, Egyptian Mau, Exotic Shorthair, Maine Coon, Manx , Ragdoll, Seychellois Short/Long Hair, Siamese, Siberian, Sphynx, Turkish Van,
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