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Test Overview:

The FGF5 gene affects the hair length of feline coat. There are seven known variants that have been identified in FGF5 gene that are allelic, resulting in long hair when there are two copies inherited. The wildtype allele is Sh and is dominant, and cats who inherit one or two copies of this Sh allele will have short hair and cats who inherit two copes of the Ih variant will have long hair. However, cats are able to inherit two of the same Ih (homozygotes) variant or one copy of one variant and one copy of another variant (compound heterozygote) and still have long hair. The Ih1-Ih5 variants also known as M1-M5.

Category:

Trait (Associated with Phenotype)

Gene:

FGF5

Variant Detected:

4 different variants detected M1(c.356insT), M2 (c.406C>T), M3 (c.474delT) and M4(c.475A>C).

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Drögemüller C, Rüfenacht S, Wichert B, Leeb T. Mutations within the FGF5 gene are associated with hair length in cats. Anim Genet. 2007 Jun;38(3):218-21. Epub 2007 Apr 13. PubMed PMID: 17433015. PubMed: 17433015 Kehler JS, David VA, Schäffer AA, Bajema K, Eizirik E, Ryugo DK, Hannah SS,O'Brien SJ, Menotti-Raymond M. Four independent mutations in the feline fibroblast growth factor 5 gene determine the long-haired phenotype in domestic cats. J Hered. 2007 Sep-Oct;98(6):555-66. Epub 2007 Sep 1. PubMed PMID: 17767004 PubMed: 17767004 Shaffer GD, Ballif BC, Meurs K, Shaffer LG, Flores-Smith H. Identification of a novel missense mutation in the fibroblast growth factor 5 gene associated with longhair in the Maine Coon Cat. Hum Genet. 2021 Nov;140(11):1517-1523. PMID: 34599367.

Associated Breed(s):

Abyssinian, African Short Hair, American Bobtail , American Curl, American Ringtail, American Shorthair, Angora, Asian, Australian Mist , Balinese, Bengal, Birman, Bombay, British Black Tipped, British Longhair, British Red Spot, British Shorthair, British Shorthair/Longhair, Burmese, Burmilla, Calico, California Spangled, Chantilly, Chartreux, Chausie, Chinchilla, Colourpoint Siberian Forest Cat, Cornish Rex, Devon Rex, Domestic Leopard Cat, Domestic Medium / Long Hair, Domestic Short Hair, Don Hairless, Don Sphynx, Egyptian Black, Egyptian Mau, European, Exotic , Exotic Longhair, Exotic Shorthair, Foreign White, German Rex, Havana Brown, Highland Fold, Himalayan, Japanese Bobtail, Javanese, Khao Manee, Korat, Kurilian Bobtail Short Haired, LaPerm , Maine Coon, Manx , Munchkin Short/Long Haired, Norwegian Forest Cat, Ocicat, Ojos Azules, Oriental , Oriental Long Hair, Oriental Short Hair, Persian , Persian Blue, Persian Colourpoint, Persian Smoke, Persian Tabby, Peterbald, PixieBob, Ragamuffin, Ragdoll, Rex , Russian Black, Russian Blue, Russian White, Savannah, Scottish Fold, Scottish Fold Long Haired, Scottish Fold Short Haired, Scottish Straight, Scottish Wildcat, Selkirk Rex, Serengeti, Seychellois Short/Long Hair, Siamese, Siberian, Siberian Forest Cat, Singapura, Snowshoe, Sokoke, Somali , Somali Long Hair, Somali Short Hair, Sphynx, Tiffany, Tonkinese, Toyger, Turkish Angora, Turkish Van, York Chocolate,
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