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Dominant White & White Spotting [W LOCUS]

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Test Overview:

The white spotting gene (S) creates white markings on a solid or patterned cat. The white spotting gene is variable in expression from white locket (face/ paws/legs/white stomach) through to solid white covering 40-60 % of the body to high grade spotting (van pattern) where most of the body is white, other than the head and tail that can resemble dominantno white, however it is rarely associated with deafness. Homozygosity vs heterozygosity for the ws allele appears to have an influence on the degree of white pigmentation. Dominant white (W) masks other colour and pattern alleles hence solid white cats may genetically be solid or patterned cats in any colour. The underlying colour will show up in any offspring that don’t inherit the Dominant white allele.

Category:

Trait (Associated with Phenotype)

Gene:

KIT

Variant Detected:

insertion over 20bp

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Dominant

Research Citation(s):

https://www.ncbi.nlm.nih.gov/pubmed/25085922
Frischknecht, M., Jagannathan, V., Leeb, T. : Whole genome sequencing confirms KIT insertions in a white cat. Anim Genet 46:98, 2015. Pubmed reference: 25515300. DOI: 10.1111/age.12246.

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