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Curly Coat - Cornish Rex

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Test Overview:

Mate two carriers or curly coated (homozygous) cats to produce curly coat kittens. Genetic testing is recommended to: Confirm breed affiliation. Identify carriers in outcross programs. Help manage breeding for desired coat traits while maintaining genetic diversity. Carriers (heterozygotes) should not be assumed to express the trait but can produce affected kittens when mated with other carriers. Responsible breeding should balance coat type desires with overall health and genetic diversity.

Category:

Trait (Associated with Phenotype)

Gene:

LPAR6

Variant Detected:

c.250_253_delTTTG

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the LPAR6 gene will reliably determine if a cat is a genetic carrier for Curly Coat - Cornish Rex.

Research Citation(s):

Zorc, M., Horvat, T., Tansek, A., Ferme, T., Dovc, P. : Selection signatures reveal candidate genes for the Cornish Rex breed-specific phenotype. Genes (Basel) 15:368, 2024. Pubmed reference: 38540427. DOI: 10.3390/genes15030368. Rodney, A.R., Buckley, R.M., Fulton, R.S., Fronick, C., Richmond, T., Helps, C.R., Pantke, P., Trent, D.J., Vernau, K.M., Munday, J.S., Lewin, A.C., Middleton, R., Lyons, L.A., Warren, W.C. : A domestic cat whole exome sequencing resource for trait discovery. Sci Rep 11:7159, 2021. Pubmed reference: 33785770. DOI: 10.1038/s41598-021-86200-7. Gandolfi, B., Alhaddad, H., Affolter, V.K., Brockman, J., Haggstrom, J., Joslin, S.E., Koehne, A.L., Mullikin, J.C., Outerbridge, C.A., Warren, W.C., Lyons, L.A. : To the root of the curl: A signature of a recent selective sweep identifies a mutation that defines the Cornish rex cat breed. PLoS One 8:e67105, 2013. Pubmed reference: 23826204. DOI: 10.1371/journal.pone.0067105.

Associated Breed(s):

Cornish Rex,
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