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Agouti

$50

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Test Overview:

The Agouti gene affects feline coat colour. It does so by regulating the temporal and spatial expression of ASIP gene, which when it is activated, it causes a switch of synthesis of eumelanin (the black pigment) to phaeomelanin (the yellow/red pigment) in the melanocyte of feline hair follicles and epidermis. Cats that have a/a genotype are able to have a solid coat colour without any tabby expression. However, cats coat colour also depends on other genes in their genome, which include loci O, B, E, Mc, Wb, Ti and C.

Category:

Trait (Associated with Phenotype)

Gene:

ASIP

Variant Detected:

a = c.123-124delCA; g.chrA3:24917970-24917971

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Complex - Mode Unknown

Research Citation(s):

Eizirik E, Yuhki N, Johnson WE, Menotti-Raymond M, Hannah SS, O'Brien SJ. Molecular genetics and evolution of melanism in the cat family. Curr Biol. 2003 Mar 4;13(5):448-53. PubMed PMID: 12620197. PubMed: 12620197 Gershony LC, Penedo MC, Davis BW, Murphy WJ, Helps CR, Lyons LA. Who's behind that mask and cape? The Asian leopard cat's Agouti (ASIP) allele likely affects coat colour phenotype in the Bengal cat breed. Anim Genet. 2014; 45(6):893-897. PubMed PMID: 25143047 PubMed: 25143047

Associated Breed(s):

Abyssinian, African Short Hair, All Breeds (Feline), American Bobtail , American Curl, American Ringtail, American Shorthair, Angora, Asian, Australian Mist , Balinese, Bengal, Birman, Bombay, British Black Tipped, British Longhair, British Red Spot, British Shorthair, British Shorthair/Longhair, Burmese, Burmilla, Calico, California Spangled, Chantilly, Chartreux, Chausie, Chinchilla, Colourpoint Siberian Forest Cat, Cornish Rex, Devon Rex, Domestic Leopard Cat, Domestic Medium / Long Hair, Domestic Short Hair, Don Hairless, Don Sphynx, Egyptian Black, Egyptian Mau, European, Exotic , Exotic Longhair, Exotic Shorthair, Foreign White, German Rex, Havana Brown, Highland Fold, Himalayan, Japanese Bobtail, Javanese, Khao Manee, Korat, Kurilian Bobtail Short Haired, LaPerm , Maine Coon, Manx , Mixed Breed / Unknown Breed (Feline), Munchkin Short/Long Haired, Norwegian Forest Cat, Ocicat, Ojos Azules, Oriental , Oriental Long Hair, Oriental Short Hair, Persian , Persian Blue, Persian Colourpoint, Persian Smoke, Persian Tabby, Peterbald, PixieBob, Ragamuffin, Ragdoll, Rex , Russian Black, Russian Blue, Russian White, Savannah, Scottish Fold, Scottish Fold Long Haired, Scottish Fold Short Haired, Scottish Short Hair, Scottish Straight, Scottish Wildcat, Selkirk Rex, Serengeti, Seychellois Short/Long Hair, Siamese, Siberian, Siberian Forest Cat, Singapura, Snowshoe, Sokoke, Somali , Somali Long Hair, Somali Short Hair, Sphynx, Tiffany, Tonkinese, Toyger, Turkish Angora, Turkish Van, York Chocolate,
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