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Vitamin D-dependent Rickets, Type IA, Variant 2 (Feline)

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Test Overview:

Genetic testing of breeding cats for CYP27B1 variants is essential to identify carriers and affected cats. Cats with two copies of the mutation (affected) should be excluded from breeding programs. Mating carriers with clear cats avoids affected offspring but produces carrier kittens. Avoid mating two carriers to reduce affected litters. Share genetic test results among breeders for informed, responsible breeding to reduce this genetic disorder.

Category:

Metabolic - Associated with the enzymes and metabolic processes of cells

Gene:

CYP27B1

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Associated Breed(s):

Mixed Breed / Unknown Breed (Feline),
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