/ 0
Store

Find Products

Mucopolysaccharidosis Type VI (Modifier) (Feline)

$50

(ONLINE PRICE)

ADD TO CART

Test Overview:

Test all breeding cats for MPS VI severe and mild variants as well as the modifier variant. Cats with two copies of the severe variant (MPSVIs/MPSVIs) will develop severe disease and must not be bred. Cats heterozygous for the severe variant (N/MPSVIs) do not show disease but can pass the mutation; these cats should be bred to clear cats (no mutation) to avoid affected kittens. Cats with one or two copies of the mild variant (N/MPSVIm or MPSVIm/MPSVIm) may carry or mildly express the disease; breeding decisions should consider genotype to avoid mild or more severe disease-producing combinations. Cats with two copies of the modifier variant alone do not develop disease but may have increased cellular granularity; breeding with cats clear of the severe variant is generally safe. Avoid breeding two cats carrying severe variants together. Gradual reduction of disease-causing alleles in the population while maintaining genetic diversity is recommended.

Category:

Metabolic - Associated with the enzymes and metabolic processes of cells

Gene:

ARSB

Variant Detected:

c.1427T>C

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing can determine if a cat is a carrier of Mucopolysaccharidosis Type VI.

Research Citation(s):

Yogalingam, G., Litjens, T., Bielicki, J., Crawley, A.C., Muller, V., Anson, D.S., Hopwood, J.J. : Feline mucopolysaccharidosis type VI - characterization of recombinant n-acetylgalactosamine 4-sulfatase and identification of a mutation causing the disease Journal of Biological Chemistry 271:27259-27265, 1996. Pubmed reference: 8910299.

Associated Breed(s):

Mixed Breed / Unknown Breed (Feline),
##parent-placeholder-8bfb4e1aa590eab8f08f837b97acf5803a5737ed##