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Methemoglobinemia, Variant 1 (Feline)

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Test Overview:

Test all breeding cats for the CYB5R3 gene mutation (Variant 1) to determine carrier status or affected status. Cats with two copies of the mutation (affected) should never be bred due to disease risk. Cats with one copy of the mutation (carriers) should be bred only with cats that are clear (no mutation) to avoid producing affected kittens. Avoid breeding two carriers together to prevent producing affected offspring. Maintain genetic diversity by careful pairing but prioritize eliminating the mutation. Inform breeders and buyers about genetic testing results for responsible breeding and management.

Category:

Metabolic - Associated with the enzymes and metabolic processes of cells

Gene:

CYB5R3

Variant Detected:

c.625G>A

Severity:

Low-Moderate. This disease can cause some discomfort and/or dysfunction in the affected animal. It does not generally affect life expectancy.

Mode of Inheritance:

Autosomal Recessive

Associated Breed(s):

Mixed Breed / Unknown Breed (Feline),
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