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Hypotrichosis with Short Life Expectancy (Feline)

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Test Overview:

Test all breeding cats for the FOXN1 mutation to identify carriers. Avoid breeding two carriers together, as this can produce affected kittens with this fatal condition. Breeding a carrier with a cat free of the mutation is safe: about half the kittens will be carriers but healthy. Test kittens before breeding to avoid unknowingly breeding carriers. Be transparent about test results with fellow breeders and buyers.

Category:

Dermatologic - Associated with the skin

Gene:

FOXN1

Variant Detected:

c.1030_1033del

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing can determine if a cat is a carrier for Hypotrichosis with Short Life Expectancy.

Research Citation(s):

Abitbol, M., Bossé, P., Thomas, A., Tiret, L. : A deletion in FOXN1 is associated with a syndrome characterized by congenital hypotrichosis and short life expectancy in Birman cats. PLoS One 10:e0120668, 2015. Pubmed reference: 25781316

Associated Breed(s):

Mixed Breed / Unknown Breed (Feline),
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