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Feline Leukocyte Adhesion Deficiency, Type 1 (Feline)

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Test Overview:

Test all breeding cats genetically for the ITGB2 deletion mutation. Avoid breeding carrier × carrier pairs to prevent affected kittens. Carrier × clear matings produce carriers or clear kittens without disease. Aim to reduce mutation frequency while maintaining gene pool diversity through selective breeding. Genetic counselling recommended to inform breeders and owners.

Category:

Immunologic - Associated with the organs and cells of the immune system

Gene:

ITGB2

Variant Detected:

c.46_58+11del

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal Recessive

Associated Breed(s):

Mixed Breed / Unknown Breed (Feline),
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