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Chylomicronemia - Lipoprotein Lipase Deficiency (Domestic Type)

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Test Overview:

Do not breed carrier × carrier pairs to avoid producing affected kittens (25% chance affected, 50% carriers, 25% clear). Carrier × clear pairings are acceptable, as all kittens will be either carriers or clear but none affected. Test all breeding cats genetic-wise for LPL mutation to determine carrier status before planning matings. Monitor reproductive performance, as homozygous LPL deficient queens may have reduced fertility and smaller litter sizes. Consider maternal genotype impact on kitten growth; kittens born to deficient mothers may have poorer growth.

Category:

Metabolic - Associated with the enzymes and metabolic processes of cells

Gene:

LPL on Chromosome B1

Variant Detected:

Base Substitution G>A

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

J Clin Invest. 1996 Mar 1;97(5):1257-66

Associated Breed(s):

Domestic Medium / Long Hair, Domestic Short Hair, Mixed Breed / Unknown Breed (Feline),
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