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Autoimmune Lymphoproliferative Syndrome

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Test Overview:

Inheritance: ALPS is an autosomal recessive genetic disorder, meaning affected cats have two copies of the mutant gene, while carriers have only one copy and are clinically healthy but can pass the mutation to offspring. Carrier Breeding: Carrier cats (with one copy of the mutation) can be safely bred only with genetically clear cats (with no copies of the mutation). About 50% of offspring from a carrier × clear mating will be carriers, while 50% will be clear. Carrier × carrier matings are not recommended because they have a 25% chance of producing affected kittens, 50% chance of producing carriers, and 25% chance of clear kittens.

Category:

Immunologic - Associated with the organs and cells of the immune system

Gene:

FASL

Variant Detected:

c.413-414InsA

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

1Aberdein D, Munday JS, Gandolfi B, Dittmer KE, Malik R, Garrick DJ, Lyons LA & 99 Lives Consortium (2017). A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats. Mammalian Genome 28, 47- 55. Aberdein D, Munday JS, Fairly RA, Vernau W & Thompson KG (2015). A novel and likely inherited lymphoproliferative disease in British Shorthair kittens. Veterinary Pathology 52, 1176-1182.

Associated Breed(s):

British Longhair, British Shorthair, British Shorthair/Longhair,
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