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Autoimmune Lymphoproliferative Syndrome

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Test Overview:

This disease is characterised by a build up of immune cells on the spleen and lymph nodes. Symptoms tend to be seen at around 6 to 8 weeks and progression tends to be quite rapid after that. Affected kittens show abdominal distension, tend to be lethargic and show weight loss due to anaemia.

Category:

Immunologic - Associated with the organs and cells of the immune system

Gene:

FASL

Variant Detected:

c.413-414InsA

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

1Aberdein D, Munday JS, Gandolfi B, Dittmer KE, Malik R, Garrick DJ, Lyons LA & 99 Lives Consortium (2017). A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats. Mammalian Genome 28, 47- 55. Aberdein D, Munday JS, Fairly RA, Vernau W & Thompson KG (2015). A novel and likely inherited lymphoproliferative disease in British Shorthair kittens. Veterinary Pathology 52, 1176-1182.

Associated Breed(s):

British Longhair, British Shorthair, British Shorthair/Longhair,
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