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Acute Intermittent Porphyria (Variant 5) (Siamese Type 2)

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Test Overview:

Since this variant is autosomal recessive, breeding two carriers risks producing affected offspring (25% per litter). Carriers are asymptomatic but can pass the mutation to offspring. Genetic testing is strongly recommended for breeding cats to identify carriers and avoid carrier × carrier matings. Responsible breeding programs should aim to reduce the frequency of this mutation while maintaining genetic diversity within the breed.

Category:

Haemolymphatic - Associated with the blood and lymph

Gene:

HMBS

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Dominant with Variable Expressivity

Associated Breed(s):

Siamese,
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