Spotting (W) Locus (Mastiff Type)*

Category:

Trait (Associated with Phenotype)

Gene:

FERV1

Variant Detected:

retrovirus insertion in KIT-FERV1 that is located in locus W

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

David, V. A., Menotti-Raymond, M., Wallace, A. C., Roelke, M., Kehler, J., Leighty, R., Eizirik, E., Hannah, S. S., Nelson, G., Schäffer, A. A., Connelly, C. J., O'Brien, S. J. & Ryugo, D. K. (2014). Endogenous retrovirus insertion in the KIT oncogene determines white and white spotting in domestic cats. G3: Genes| Genomes| Genetics, 4(10), 1881-1891. Frischknecht, M., Jagannathan, V., & Leeb, T. (2015). Whole genome sequencing confirms KIT insertions in a white cat. Animal genetics, 46(1), 98-98.