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Hairlessness (American Hairless Terrier Type)

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Test Overview:

The SGK3 gene impacts the presence or absence of coat in the American Hairless Terrier. SGK3 is critical to proper hair follicle development and maintenance. Variants in this gene cause juvenile hair loss and Alopecia, resulting in a hairless dog.

Category:

Trait (Associated with Phenotype)

Gene:

SGK3

Variant Detected:

rh1 = Chr29:16366702_16366705delTTAG (American Hairless Terrier Type)

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the SGK3 gene will reliably determine if a dog is a genetic carrier of the rh1 variants that cause juvenile Alopecia in the American Hairless Terrier.

Research Citation(s):

Hytönen MK, Lohi H. A frameshift insertion in SGK3 leads to recessive hairlessness in Scottish Deerhounds: a candidate gene for human alopecia conditions. Hum Genet. 2019 138, 535–539. https://doi.org/10.1007/s00439-019-02005-9 Parker HG, Harris A, Dreger DL, Davis BW, Ostrander EA. 2017 The bald and the beautiful: hairlessness in domestic dog breeds. Phil. Trans. R. Soc. B 372: 20150488. http://dx.doi.org/10.1098/rstb.2015.0488

Associated Breed(s):

American Hairless (Rat) Terrier,
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