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Cocoa/Brown HPS3 [French Bulldog Type] = Co

Cocoa/Brown HPS3 [French Bulldog Type] = Co

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Test Overview:

Test breeding dogs for the HPS3^co mutation. Breed carriers only to clear dogs to prevent cocoa offspring unless breeding for the cocoa coat color intentionally. Avoid breeding two carriers if the cocoa coat is not desired, as this results in 25% affected puppies. Use genetic information alongside other coat genotype data (like TYRP1) for informed breeding strategies.

Category:

Trait (Associated with Phenotype)

Gene:

HPS3

Variant Detected:

c.2420G>A or p.(Trp807*)

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive with Incomplete Penetrance

Research Citation(s):

Genes 2020, 11(6), 636; https://doi.org/10.3390/genes11060636

Associated Breed(s):

American Bulldog , American Bully (Micro/Pocket/Classic/XL), Boston Bulldog, British Bulldog, French Bulldog,
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