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B Locus (Brown) - Siberian Husky Type

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Test Overview:

Genetic testing for all four known B Locus variants (bc, bs, bd, bh) is advisable for precise identification of carrier and affected dogs. Avoid breeding two carriers or two brown dogs if the goal is to prevent brown coat color in litters. Breed carriers only to genetically clear (black) dogs to avoid producing brown puppies, while acknowledging some puppies may be carriers. If brown coat color is desired, carriers or brown dogs can be selectively bred. Knowledge of B Locus status supports accurate coat color prediction and breed standard adherence.

Category:

Trait (Associated with Phenotype)

Gene:

TYRP1

Variant Detected:

bh = G>A, Chr11:33317814 (Siberian Husky Type)

Severity:

It is a trait and so is tested based on preference, not usually for health concerns.

Mode of Inheritance:

Autosomal Recessive

Research Citation(s):

Van Buren SL, Mickelson JR, Minor KM. A novel TYRP1 mutation associated with brown coat color in Siberian huskies. Anim Genet. 2021 Apr;52(2):245-246. doi: 10.1111/age.13037. Epub 2021 Jan 9. [PubMed: 33421162]

Associated Breed(s):

Mixed Breed, Siberian Husky,
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