X-Linked Hereditary Nephropathy - Navasota Dog Type

Category:

Urogenital (Associated with the Urinary and Genital Tracts)

Gene:

COL4A5

Variant Detected:

deletion on chromosome X

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal X-Linked

Research Citation(s):

Benali, S. L., Lees, G. E., Nabity, M. B., Aricò, A., Drigo, M., Gallo, E., Giantin, M., & Aresu, L. (2016). X-Linked Hereditary Nephropathy in Navasota Dogs: Clinical Pathology, Morphology, and Gene Expression During Disease Progression. Veterinary Pathology.

Associated Breed(s):

Unknown,