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Lundehund Syndrome

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Test Overview:

Lundehund Syndrome affects dogs and is an inherited gastrointestinal (GI) disease. Dogs affected by this disease often display wide range in age of onset (but typically present between 2 to 10 years of age) with vomiting, diarrhoea, hair loss, weight loss and lethargy. Some dogs may develop fluid in their abdominal cavity and swelling of their limbs. The blood work of affected dogs will typically reveal decreased protein and calcium levels, as well as other abnormalities that are consistent with severe GI disease. The treatment with anti-inflammatory drugs, specialised diets, and vitamin supplementation can help, however, the prognosis of affected dogs differs greatly, from minor, often recurrent, chronic diarrhoea to severe treatment-resistant disease resulting in death or euthanasia.

Category:

Digestive system / Gastrointestinal - Associated with the organs and structures of the digestive system

Gene:

LEPREL1

Variant Detected:

chr34:22046092 (canFam3): G/C

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the LEPREL1 gene in dogs will reliably determine if a dog is a genetic carrier of Lundehund Syndrome.

Research Citation(s):

Berghoff N, Ruaux CG, Steiner JM, Williams DA. (2007). Gastroenteropathy in Norwegian Lundehund. Compendium (Yardley, PA). 29. 456-65, 468. [Not in PubMed] Metzger J, Pfahler S, Distl O. Variant detection and runs of homozygosity in next generation sequencing data elucidate the genetic background of Lundehund syndrome. BMC Genomics. 2016 Aug 2;17:535. doi: 10.1186/s12864-016-2844-6. [PubMed: 27485430]

Associated Breed(s):

Mixed Breed,
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