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Leigh-Like Subacute Necrotising Encephalopathy

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Test Overview:

Leigh-Like Subacute Necrotising Encephalopathy affects dogs and is a neurodegenerative disorder. This disease is characterised by symmetrical, bilateral and necrotic lesions in the basal ganglia and brainstem. It is a mitochondrial disease caused by defects from the respiratory chain and leads to impaired energy production. Symptoms include seizures, dysphagia (difficulties swallowing), paresis (weakness), visual deficits, neurological deficits, behavioural changes and ataxia (incoordination). This disease is usually fatal.

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

SLC19A3

Severity:

Severe. This disease has a high impact on affected animals, either with severe clinical signs causing significant suffering, or carrying a rapidly fatal course.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the SLC19A3 gene will reliably determine if a dog is a genetic carrier of Leigh-Like Subacute Necrotising Encephalopathy.

Associated Breed(s):

Mixed Breed,
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