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Hereditary Methemoglobinemia, Variant 3

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Test Overview:

Hereditary Methemoglobinemia, Variant 3 affects dogs and is a genetic disease where the dogs blood contains too much methemoglobin and therefore the ability for oxygen to be delivered to tissues becomes impaired. Symptoms can include exercise intolerance, fatigue, shortness of breath, purplish discolouration of the gums and skin (cyanosis).

Category:

Haemolymphatic - Associated with the blood and lymph

Gene:

CYB5R3

Severity:

Moderate. This disease can cause significant signs of discomfort and/or dysfunction in affected animals. It may involve relatively high treatment/management costs, and can sometimes reduce life expectancy.

Mode of Inheritance:

Autosomal Recessive

Recommended Screening:

Genetic testing of the CYB5R3 gene will reliably determine if a dog is a genetic carrier of Hereditary Methemoglobinemia, Variant 3.

Associated Breed(s):

Mixed Breed,
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